Serie A leaders Inter Milan will be looking to bounce back from their Champions League elimination at Old Trafford as they host fourth-placed Fiorentina on Sunday night.
Coach Jose' Mourinho was adamant that the last-16 tie could have gone the other way if the rub of the green had been with Inter and he is sure to instill fresh faith in a squad that will feel unlucky to have gone out.
Zlatan Ibrahimovic in particular may be in subdued mood after yet again failing to be a match-winner at the highest club level, despite coming close twice and hitting the bar.
A shot-in-the-arm may be needed against feisty Fiorentina who are itching to get back on song after last week's 2-0 home upset by Palermo.
''We're still on track for Champions League qualification and we'll show it against Inter,'' said Adrian Mutu.
The Palermo win left the Florentines five points below AC Milan and only one above Genoa and Roma.
Third-placed Milan will again be without Kaka when they visit 15th-placed Siena earlier on Sunday but David Beckham is expected to have recovered from a twisted ankle and Ronaldinho may also be available.
Coach Carlo Ancelotti is expected to keep faith with striker Pippo Inzaghi who scored all the goals in last week's 3-0 win over Atalanta.
Juventus, seven points behind Inter in second place, will be trying to put Tuesday's defeat to Chelsea behind them as they host 16th-placed Bologna on Saturday night.
David Trezeguet is expected to get more playing time but the Bianconeri will be without right winger Mauro Camoranesi and midfielder Momo Sissoko whose season has ended.
Roma travel to 14th-placed Sampdoria on Sunday with the bitter taste of a penalty shoot-out defeat to Arsenal and skipper Francesco Totti among the walking wounded.
Napoli, in 11th place, aim to get Roberto Donadoni's term as manager off to a bright start in their Sunday visit to bottom club Reggina.